基本信息：

李海涛，博士，二级教授，博士生导师，曾任湖南师范大学教务处副处长、评建办常务副主任、固定资产管理处处长，湖南安全技术职业学院院长、党委书记。主要从事化学生物学及功能材料等领域的研究。主持国家自然科学基金面上项目4项，省部级重点及一般项目多项。以第一作者和通讯作者在Angewandte Chemie-International Edition， Biosensors and Bioelectronicsthis. Green Chemistry，Talanta.等国际著名刊物上发表研究论文160余篇，获国家授权发明专利5项。

主持课题（部分）

1.国家自然科学基金项目（21977028）基因毒素Colibactind的荧光分析与结直肠癌预警新方法，在研

2.国家自然科学基金项目（21675051）近红外比率型氧化还原可逆荧光探针的设计合成及其在细胞内活性氧物种原位动态检测中的应用，结题

3.国家自然科学基金项目（21375037）新型双光子探针的设计、合成及在生物或许物质检测中的应用，结题

4.国家自然科学基金项目（21075037）多功能亲水性链珠结构分子导线合成、电子传输机理以及在免疫分析中的应用研究，结题

5.湖南省自然科学基金重点项目（13JJ2020）新型荧光探针的设计合成及在小分子检测中的应用，结题

代表性论文（部分）

1. Li, Y., Zhou, Z., Chen, S., ...Li, H., Zhang, Y. Mitochondria-targeting fluorescent sensor with high photostability and permeability for visualizing viscosity in mitochondrial malfunction, inflammation, and AD models. Analytica Chimica Acta，2023, 1250, 340967

2. Zhao, K., Xie, R., Zhou, Z., ...Zhang, Y., Li, H. A turn-on NIR fluorescent probe for risk-assessing oxidative stress in cabbage roots under abiotic stress. Talanta, 2023, 258, 124402

3. Zile Zhou, Shengyou Chen, Yinghui Huang, Biao Gu, Jiaqi Li, Cuiyan Wu, Peng Yin, Youyu Zhang*, Haitao Li*, Simultaneous visualization and quantification of copper (II) ions in Alzheimer’s disease by a near-infrared fluorescence probe. Biosensors and Bioelectronics, 2022, 198, 113858.

4. Zile Zhou, Peijuan Li, Zhihui Liu, Cuiyan Wu, Youyu Zhang, Haitao Li *，Construction of a unique fluorescent probe for rapid and highly sensitive detection of glutathione in living cells and zebrafish. Talanta，2022，243，123364

5. Zile Zhou, Huihui Tang, Shengyou Chen, Yinghui Huang, Xiaohua Zhu*, Haitao Li*, Youyu Zhang, Shouzhuo Yao, A turn-on red-emitting fluorescent probe for determination of copper(II) ions in food samples and living zebrafish. Food Chemistry, 2021, 343, 128513.

6. Biao Gu, Mengqin Liu, Cong Dai, Zile Zhou, Dongqing Tang, Siping Tang*, Youming Shen*, Haitao Li*. Rational construction of a novel ratiometric far-red fluorescent probe with excellent water solubility for sensing mitochondrial peroxynitrite. Sensors and Actuators: B. Chemical, 2021, 344, 130246.

7. Xiao Pang, Yaqian Li, Qiujun Lu, Ziqi Ni, Zile Zhou, Ruihua Xie, Cuiyan Wu, Haitao Li* Youyu Zhang*, A turn-on near-infrared fluorescent probe for visualization of endogenous alkaline phosphatase activity in living cells and zebrafish. Analyst, 2021, 146, 521-528.

8. Biao Gu, Cuiyan Wu, Chunxiang Zhang, Shihui He, Siping Tang*, Haitao Li*, Youming Shen*, A morpholino hydrazone-based lysosome-targeting fluorescent probe with fast response and high sensitivity for imaging peroxynitrite in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021, 262, 120100.

9. Cuiyan Wu，Ziqi Ni，Peijuan Li，Yaqian Li，Xiao Pang，Ruihua Xie，Zile Zhou，Haitao Li* ， Youyu Zhang, A near-infrared fluorescent probe for monitoring and imaging of beta-galactosidase in living cells. Talanta, 2020, 219, 121307.

10. Xiao Pang，Yaqian Li，Zile Zhou，Qiujun Lu，Ruihua Xie，Cuiyan Wu*，Youyu Zhang，Haitao Li*, Visualization of endogenous beta-galactosidase activity in living cells and zebrafish with a turn-on near-infrared fluorescent probe. Talanta, 2020, 217, 121098.

11. .Cuiyan Wu，Ruihua Xie，Xiao Pang，Yaqian Li，Zile Zhou，Haitao Li*, A colorimetric and near-infrared ratiometric fluorescent probe for hydrazine detection and bioimaging. Spectrochimica Acta Part A-Molecular and Biomolecular Spectroscopy, 2020, 243, 118764.

12. .Ruihua Xie，Yaqian Li，Zile Zhou，Xiao Pang，Cuiyan Wu，Peng Yin，Haitao Li*, A near-infrared excitation/emission fluorescent probe for imaging of endogenous cysteine in living cells and zebrafish. Analytical and Bioanalytical Chemistry, 2020 412,(23),5539-5550.

13. Guoxing Yin, Tingting Niu, Ting Yu, Yabing Gan, Xinyu Sun, Peng Yin*, Haimin Chen, Youyu Zhang, Haitao Li*, Shouzhuo Yao, Simultaneous Visualization of Endogenous Homocysteine, Cysteine, Glutathione, and their Transformation through Different Fluorescence Channels. Angewandte Chemie-International Edition, 2019, 58, 4557-4561.

14. Guo-xing Yin, Ting-ting Niu, Ya-bing Gan, Ting Yu, Peng Yin*, Hai-min Chen*, You-yu Zhang, Hai-tao Li*, Shou-zhuo Yao, A Multi-signal Fluorescent Probe with Multiple Binding Sites for Simultaneous Sensing of Cysteine, Homocysteine, and Glutathione. Angewandte Chemie-International Edition, 2018, 130, 5085-5088.

15. Qiujun Lu, Cuiyan Wu, Dan Liu, Haiyan Wang, Wei Su, Haitao Li*, Youyu Zhang, Shouzhuo Yao, A facile and simple method for synthesis of graphene oxide quantum dots from black carbon. Green Chemistry, 2017, 19, 900-904.

16. Meiling Liu, Qiong Chen, Cailang Lai, Youyu Zhang, Jianhui Deng, Haitao Li*, Shouzhuo Yao, A double signal amplification platform for ultrasensitive and simultaneous detection of ascorbic acid, dopamine, uric acid and acetaminophen based on a nanocomposite of ferrocene thiolate stabilized Fe3O4@Au nanoparticles with graphene sheet. Biosensors & Bioelectronics, 2013, 48, 75-81.

17. Zile Zhou, Yaqian Li, Wei Su, Biao Gu, Hai Xu, Cuiyan Wu, Peng Yin, Haitao Li*, Youyu Zhang, A dual-signal colorimetric and near-infrared fluorescence probe for the detection of exogenous and endogenous hydrogen peroxide in living cells. Sensors and Actuators B-Chemical, 2019, 280, 120-128

18. Biao Gu, Liyan Huang, Zhifeng Xu, Zhen Tan, Meng Hu, Zitun Yang, Yanxia Chen, Cheng Peng, Wenpei Xiao, Donghai Yu, Haitao Li*, A reaction-based, colorimetric and near-infrared fluorescent probe for Cu2+ and its applications. Sensors and Actuators B-Chemical, 2018, 273, 118-125.

19. Biao Gu, Wei Su, Liyan Huang, Cuiyan Wu, Xiaoli Duan, Yaqian Li, Hai Xu, Zhen Huang, Haitao Li*, Shouzhuo Yao, Real-time tracking and selective visualization of exogenous and endogenous hydrogen sulfide by a near-infrared fluorescent probe. Sensors and Actuators B-Chemical, 2018, 255, 2347-2355.

20. Linping Wang, Yue Meng, Qiong Chen, Jianhui Deng, Youyu Zhang∗ , Haitao Li∗ , Shouzhuo Yao， Simultaneous electrochemical determination of dihydroxybenzene isomers based on the hydrophilic carbon nanoparticles and ferrocene-derivative mediator dual sensitized graphene composite，Electrochimica Acta 2013，92，216– 225

21. Biao Gu, Liyan Huang, Wei Su, Xiaoli Duan, Haitao Li*, Shouzhuo Yao, A benzothiazole-based fluorescent probe for distinguishing and bioimaging of Hg2+ and Cu2+. Analytica Chimica Acta, 2017, 954, 97-104.

22. Biao Gu, Naxiu Mi, Youyu Zhang, Pen Yin, Haitao Li*, Shouzhuo Yao, A tetraphenylimidazole-based fluorescent probe for the detection of hydrogen sulfide and its application in living cells. Analytica Chimica Acta, 2015, 879, 85-90.

23. Liyan Huang, Zitun Yang, Zile Zhou, Yaqian Li, Siping Tang, Wenpei Xiao, Meng Hu, Cheng Peng, Yanxia Chen, Biao Gu, Haitao Li*, A dual colorimetric and near-infrared fluorescent turn-on probe for Hg2+ detection and its applications. Dyes and Pigments, 2019, 163, 118-125.

24. Yaqian Li , Ruihua Xie , Xiao Pang , Zile Zhou , Hai Xu , Biao Gu , Cuiyan Wu , Haitao Li,* Youyu Zhang，Aggregation-induced emission fluorescent probe for monitoring endogenous alkaline phosphatase in living cells，Talanta， 2019，205，120143

25. Yaqian Li, Wei Su, Zile Zhou, Zhen Huang, Cuiyan Wu, Peng Yin, Haitao Li*, Youyu Zhang, A dual-response near-infrared fluorescent probe for rapid detecting thiophenol and its application in water samples and bio-imaging. Talanta, 2019, 199, 355-360.

26. Cuiyan Wu, Hai Xu, Yaqian Li, Ruihua Xie, Peijuan Li, Xiao Pang, Zile Zhou, Biao Gu, Haitao Li*, Youyu Zhang, An ESIPT-based fluorescent probe for the detection of phosgene in the solution and gas phases. Talanta, 2019, 200, 78-83.

27. Hai Xu, Biao Gu, Yaqian Li, Zhen Huang, Wei Su, Xiaoli Duan, Peng Yin, Haitao Li*, Shouzhuo Yao, A highly selective, colorimetric and ratiometric fluorescent probe for NH2NH2 and its bioimaging. Talanta, 2018, 180, 199-205.

28. Ting Yu, Guoxing Yin, Tingting Niu, Peng Yin*, Haitao Li*, Youyu Zhang, Haimin Chen,，Ying Zeng, Shouzhuo Yao, A novel colorimetric and fluorescent probe for simultaneous detection of SO32-/HSO3- and HSO4- by different emission channels and its bioimaging in living cells. Talanta, 2018, 176, 1-7.

29. Biao Gu, Liyan Huang, Jiali Hu, Jingjing Liu, Wei Su, Xiaoli Duan, Haitao Li*, Shouzhuo Yao，Highly selective and sensitive fluorescent probe for the detection of nitrite. Talanta, 2016, 152, 155-161.

30. Xiaoyu Fan, Haitao Li*, Jie Zhao, Fanbo Lin, Lingli Zhang, Youyu Zhang, Shouzhuo Yao, A novel label-free fluorescent sensor for the detection of potassium ion based on DNAzyme. Talanta, 2012, 89, 57-62.

31. Meiling Liu, Jianhui Deng, Cailang Lai, Qiong Chen, Qiangqing Zhao, Youyu Zhang, Haitao Li*, Shouzhuo Yao, Synthesis, characterization of conjugated oligo-phenylene-ethynylenes and their supramolecular interaction with beta-cyclodextrin for salicylaldehyde detection. Talanta, 2012, 100, 229-238.

32. Hai Xu, Zhen Huang, Yaqian Li, Biao Gu, Zile Zhou, Ruihua Xie, Xiao Pang, Haitao Li*, Youyu Zhang, A highly sensitive naked-eye fluorescent probe for trace hydrazine based on 'C-CN' bond cleavage. Analyst, 2018, 143, 4354-4358.